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VITOPHER-n
(Natural Vitamin E
supplement)
Uses:
- Vitamin-E supplement
- Antioxidant
- Improves Sperm count, motility and morphology
- Arrests progress of Prostate Cancer
- Arrests progress of Peyronie’s Disease
- Improves wound healing
- Beneficial in arthritis
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Vitamin E (alpha tocopherol) is an anti-oxidant
that assists in maintaining cell integrity. It is easily obtained from
sunflower, safflower, canola, and olive oils; also from many grains, nuts,
fruits as well as fatty parts of meats.
Only a small amount of vitamin E is needed to meet normal daily
requirements. However, research using vitamin E at far higher doses than the
daily requirement has provided preliminary evidence that it may be helpful
for preventing or treating various medical conditions. These uses include
treating menstrual pain, cardiac autonomic neuropathy (a complication of
diabetes), low sperm count, restless leg syndrome, inflammation of eye
tissues, Alzheimer’s, Parkinson’s and rheumatoid arthritis. Vitamin E also
might improve seniors’ immune response.
Vitamin E was long touted for preventing cardiovascular disease. But most of
the recent studies have failed to support that premise. However, many of
these studies looked only at people already at high risk for heart disease
or with a prior history of the condition. Vitamin E also once was considered
a promising treatment for preventing several kinds of cancer. However,
current evidence points only to the prevention of prostate cancer.
HEALTH BENEITS of VITAMIN E
Antioxidant properties: “Vitamin E” has distinctive antioxidant activities.
It protects body cells from the free radicals formed when fat undergoes
oxidation. Free radicals also come from environmental exposures, such as
cigarette smoke, air pollution, and ultraviolet radiation from the sun. Free
radicals are highly energetic and react rapidly with oxygen to form reactive
oxygen species (ROS). The ROS, which are commonly produced when the body
converts food to energy, in turn damage cells and might contribute to the
development of cardiovascular disease and cancer. Antioxidants like Vitamin
E protect cells from the damaging effects of ROS.
Male Infertility:
Improves sperm count, motility (Arch. Androl. 49(2):83-94,
2003) and Morphology. Improves oligiaesthenospermia by about 3 fold when
used in combination with clomiphene citrate. [Fertil Steril. 2009 Mar 5. [PubMed
search]
Immune Function: Vitamin E is involved in immune function and, as shown
primarily by in vitro studies of cells, cell signaling, regulation of gene
expression, and other metabolic processes. Alpha-tocopherol inhibits the
activity of protein kinase C, an enzyme involved in cell proliferation and
differentiation in smooth muscle cells, platelets, and monocytes.
Protection against cancer. One recent Finnish study reported a reduced
incidence of prostate cancer in male smokers who took 50 IU Vitamin E daily
for five to eight years. Vitamin E might also block the formation of
carcinogenic nitrosamines formed in the stomach from nitrites in foods and
protect against cancer by enhancing immune function [7]. Some research links
higher intakes of vitamin E with a decreased incidence of breast and
prostate cancers [8].
Prevention of & delaying of cataracts and macular degeneration. Liquid
vitamin E supplementation cuts the incidence of cataracts in half. The risk
of late stage macular degeneration, the leading cause of blindness in the
elderly, is significantly lower in older adults who take high levels of
Vitamin E [9].
Vitamin E helps prevent Alzheimer disease, particularly if combined with
vitamin C, both taken in high doses (greater than 400 IUs a day for Vitamin
E). Vitamin E boosts immune function. Some studies have shown improved
immune responses in older people who take liquid vitamin E supplements [10].
Vitamin E could help prevent or delay coronary heart disease (CHD). In vitro
studies have found that the nutrient inhibits oxidation of low-density
lipoprotein (LDL) cholesterol, thought to be a crucial initiating step for
atherosclerosis. Vitamin E might also help prevent the formation of blood
clots that could lead to a heart attack or venous thromboembolism.
• Vitamin E
decreases the incidence of ischaemic heart disease (Gey et al.
1991).
Others: • Decreases the incidence of cataract (Packer, 1991; 1992).•
Decreases the incidence of osteoarthritis (Blankenhorn, 1986). • Decreases
the incidence of rheumatoid arthritis (Kheir El-dein et al. 1992).
Natural Vit E vs. Synthetic
Vitamin E is available in many different forms. In its natural form, vitamin
E is designated d-, as in d-alpha-tocopherol, while its synthetic forms are
dl-, as in dl-alpha-tocopherol.
Our body only recognizes the d form. Although the l form has antioxidant
activity, it may actually inhibit the d-form from entering cell membranes.
Therefore, natural vitamin E (the d form) has greater benefit than the
synthetic (dl). Research has shown that natural vitamin E is better retained
and more biologically active than synthetic. Both forms of vitamin E are
absorbed equally well through the gut, but the liver clearly prefers the
natural form, transferring it to lipoproteins to be transported through the
blood for deposition into the tissues.
Natural vitamin E supplements also contain several other tocopherols
including the tocotrienols offering greater health benefit. For example,
while the vitamin E activity of alpha-tocotrienol is rated at 30% compared
to alpha-tocopherol’s 100%, alpha-tocotrienol actually showed greater
anti-tumor activity. Natural vitamin E is retained in humans at least two
times greater than the synthetic form of the supplement, according to a
study published in the American Journal of Clinical Nutrition (1998), and is
twice as effective.
Recommended Intakes
Intake recommendations for vitamin E and other nutrients are provided in the
Dietary Reference Intakes (DRIs) developed by the Food and Nutrition Board (FNB)
at the Institute of Medicine of The National Academies (formerly National
Academy of Sciences).
The FNB’s vitamin E recommendations are for alpha-tocopherol alone, the only
form maintained in plasma. Recommended Daily Allowances (RDAs) for vitamin E
(in mg) (1 mg of alpha-tocopherol is equivalent to 1.49 IU of the natural
form or 2.22 IU of the synthetic form) are : Birth to 6 months - 4 mg; 7-12
months - 5 mg; 1-3 years - 6 mg; 4-8 years- 7 mg; 9-13 years - 11 mg; 14+
years - 15 mg; Pregnant women - 15 mg; Lactating women - 19 mg.
Sources of Vitamin E
Food: Numerous foods provide vitamin E. Nuts, seeds, and vegetable oils are
among the best sources of alpha-tocopherol, and significant amounts are
available in green leafy vegetables and fortified cereals.
Wheat germ oil,
Almonds, dry roasted,
Sunflower seeds, dry roasted,
Sunflower oil,
Safflower oil,
Peanut butter,
Peanuts, dry roasted
Corn oil
Broccoli
Soybean oil
Mango,
Spinach... among others
Vitamin E Intakes : The diets of most Indians provide less than the
Recommended Daily Allowance (RDA) levels of vitamin E.
Vitamin E Deficiency : Frank vitamin E deficiency is rare and overt
deficiency symptoms have not been found in healthy people who obtain little
vitamin E from their diets. Premature babies of very low birth weight
(<1,500 grams) might be deficient in vitamin E.
Because the digestive tract requires fat to absorb vitamin E, people with
fat-malabsorption disorders are more likely to become deficient in Vit E
than people without such disorders.
Health Risks from Excessive Vitamin E
Research has not found any adverse effects from consuming vitamin E in food.
However, high doses of alpha-tocopherol supplements can cause hemorrhage and
interrupt blood coagulation in animals, and in vitro data suggest that high
doses inhibit platelet aggregation. Doses of up to 1,000 mg/day (1,500 IU/day
of the natural form or 1,100 IU/day of the synthetic form) in adults appear
to be safe. [6]. Tolerable Upper Intake Levels (ULs) for Vitamin E : 1-3
years - 200 mg; 4-8 years - 300 mg; 9-13 years - 600 mg; 14-18 years - 800
mg; 19+ years - 1,000 mg.
Interactions with Medications
Vitamin E supplements have the potential to interact with several types of
medications. People taking these and other medications on a regular basis
should discuss their vitamin E intakes with their healthcare providers.
Anticoagulant and antiplatelet medications
Simvastatin and niacin
Chemotherapy and radiotherapy
General Guidelines:
“Nutrient needs should be met primarily through consuming foods. Foods
provide an array of nutrients and other compounds that may have beneficial
effects on health. In certain cases, fortified foods and dietary supplements
may be useful sources of one or more nutrients that otherwise might be
consumed in less than recommended amounts. However, dietary supplements,
while recommended in some cases, cannot replace a healthful diet.” (2005
Dietary Guidelines for Americans).
A healthy diet is one that:
• Emphasizes a variety of fruits, vegetables, whole grains, and fat-free or
low-fat milk and milk products.
• Includes lean meats, poultry, fish, beans, eggs, and nuts.
• Is low in saturated fats, trans fats, cholesterol, salt (sodium), and
added sugars.
• Stays within your daily calorie needs.
References:
1. Traber MG. Vitamin E. In: Shils ME, Shike M, Ross AC, Caballero B,
Cousins R, eds. Modern Nutrition in Health and Disease. 10th ed. Baltimore,
MD: Lippincott Williams & Wilkins, 2006;396-411.
2. Traber MG. Vitamin E regulatory mechanisms. Annu Rev Nutr 2007;27:347-62.
[PubMed abstract]
3. Sen CK, Khanna S, Roy S. Tocotrienols: vitamin E beyond tocopherols. Life
Sci 2006;78:2088-98. [PubMed abstract]
4. Dietrich M, Traber MG, Jacques PF, Cross CE, Hu Y, Block G. Does
ã-tocopherol play a role in the primary prevention of heart disease and
cancer? A review. Am J Coll Nutr 2006;25:292-9. [PubMed abstract]
5. Verhagen H, Buijsse B, Jansen E, Bueno-de-Mesquita B. The state of
antioxidant affairs. Nutr Today 2006;41:244-50.
6. Institute of Medicine. Food and Nutrition Board. Dietary Reference
Intakes: Vitamin C, Vitamin E, Selenium, and Carotenoids. Washington, DC:
National Academy Press, 2000.
7. Weitberg AB, Corvese D. Effect of vitamin E and beta-carotene on DNA
strand breakage induced by tobacco-specific nitrosamines and stimulated
human phagocytes. J Exp Clin Cancer Res 1997;16:11-4. [PubMed abstract]
8. Chan JM, Stampfer MJ, Giovannucci EL. What causes prostate cancer? A
brief summary of the epidemiology. Semin Cancer Biol 1998;8:263-73. [PubMed
abstract]
9. Leske MC, Chylack LT Jr, He Q, Wu SY, Schoenfeld E, Friend J, et al.
Antioxidant vitamins and nuclear opacities: the longitudinal study of
cataract. Ophthalmology 1998;105:831-6. [PubMed abstract]
10. Sano M, Ernesto C, Thomas RG, Klauber MR, Schafer K, Grundman M, et al.
A controlled trial of selegiline, alpha-tocopherol, or both as treatment for
Alzehimer’s disease. N Engl J Med 1997;336:1216-22. [PubMed abstract]
Disclaimer
• The information in this document does not replace medical advice.
• Before taking an herb or a botanical, consult a doctor or other health
care provider-especially if you have a disease or medical condition, take
any medications, are pregnant or nursing, or are planning to have an
operation.
• Before treating a child with an herb or a botanical, consult with a doctor
or other health care provider.
• Like synthetic drugs, herbal or botanical preparations have chemical and
biological activity. They may have side effects. They may interact with
certain medications. These interactions can cause problems and can even be
dangerous.
If you have any unexpected reactions to an herbal or a botanical
preparation, inform your doctor or other health care provider.
Packing
In containers of 30 caps.
Dosage and Use
Take one capsule daily with a fat-containing meal, or as recommended by a
healthcare practitioner.
Available through:*
Rishi Pharma
Marketing,
40 Ind. Estate,
SAMALKOT - 533 440 A.P.
0884-2327454
rp@abhisarika.com
* Available in India only.
order online
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30 Caps Rs. 450
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